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In Sister Carrie, Dreiser portrayed a changing society, writing about a young woman who flees rural life for the city (Chicago) and struggles with poverty, complex relationships with men, and prostitution. It sold poorly and was considered controversial because of moral objections to his featuring a country girl who pursues her dreams of fame and fortune through relationships with men.

The book has since acquired a considerable reputation. It has been called the "greatest of all American urban novels." It was adapted as a 1952 film by the same name, directed by William Wyler and starring Laurence Olivier and Jennifer Jones.

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